Diagnosis drug resistance in low–resource settings: Practical approaches using GeneXpert
نویسندگان
چکیده
منابع مشابه
ADVANCES IN TB DIAGNOSIS AND DRUG-SUSCEPTIBILITY TESTING GeneXpert Ultra
Diagnosing tuberculosis (TB) is the first step to being able to treat it and prevent transmission. New guidelines from the World Health Organization (WHO) note that diagnosis should be “available free of charge to all persons with TB and populations at risk.”1 Yet an estimated over four million people with TB went undiagnosed or unreported to national treatment programs in 2015; India, Indonesi...
متن کاملTuberculosis diagnosis in resource-limited settings: Clinical use of GeneXpert in the diagnosis of smear-negative PTB: a case report.
BACKGROUND The Xpert MTB/RIF test (GeneXpert) has recently been endorsed for use in resource-limited settings for the diagnosis of tuberculosis and drug resistant-tuberculosis. In resource-limited settings, GeneXpert has been used predominantly for research and there is little experience with its use in day-to-day management of patients. CASE SUMMARY We describe a case of a 46 year old HIV-in...
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Chemoresistance is one of the main obstacles to the success of cancer treatment and one of the most important causes of death in patients. In the last decade, progress in high-throughput technologies, including microarray, sequencing, and bioinformatics has greatly resulted in cancer gene profiling and identification of biomarkers for cancer prognosis and prediction. This has greatly improved t...
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Multidrug-resistant (MDR) and extensively drug resistant (XDR) strains of Mycobacterium tuberculosis pose major problems for global health. The GeneXpert MTB/RIF (Xpert) assay rapidly detects resistance to rifampin (RIFr), but for detection of the additional resistance that defines MDR-TB (MDR tuberculosis) and XDR-TB, and for molecular epidemiology, specimen cultures and a biosafe infrastructu...
متن کاملAssessments of HIV drug resistance mutations in resource-limited settings.
At the end of 2009, 5.25 million persons were receiving antiretroviral therapy (ART) worldwide, representing an 10fold increase over a period of 5 years [1]. The global scale-up of ART has led to an inevitable increase in HIV drug resistance (HIVDR) and a pool of resistant virus available to establish new infections. The report by Sungkanuparph et al in this issue highlights the need for streng...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2012
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2012.05.979